AppleWise 600 mg, 30 vegetarian capsules

Brand: Life Extension Sold By: TopSelected
$53.70 In Stock
Ships from United States Arrives in 7-14 business days
Item can be returned in its original condition for a full refund or replacement within 30 days of receipt.
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16
July2026
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27
July2026
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AppleWise 600 mg, 30 vegetarian capsules

AppleWise 600 mg, 30 vegetarian capsules

$53.70

Product Details

AppleWise

600 mg, 30 vegetarian capsules Item # 01625UPC: 737870162537




What Is AppleWise?

Like green tea and pomegranates, apples contain antioxidant-rich polyphenols. AppleWise contains an apple polyphenol called phloridzin to support healthy levels of oxidative stress and already-healthy blood sugar levels, while encouraging healthy blood vessel function. It also helps support cellular health and healthy DNA function.

Take advantage of the broad range of health benefits in this apple polyphenol-based formula for overall health.

AppleWise Benefits

  • Supports cardiovascular health
  • Supports blood sugar levels already within normal range
  • Helps inhibit oxidative stress
  • Encourages healthy cell division to support colon health



An Apple a Day for Multiple Benefits

The age-old adage about an apple a day really does hold true, as the polyphenol extracts derived from apples can help support a wide range of health benefits to maintain overall health. Primarily found in the skins of apples, the antioxidant properties of these polyphenols support heart health, colon health and healthy DNA function, promoting a comprehensive range of health benefits.




Apple polyphenols are powerful antioxidants. They help inhibit glycation and promote a healthy inflammatory response. Apple polyphenols also help support a healthy cardiovascular system, cell division, blood sugar levels already within normal range and healthy immune function.

Apple Polyphenols May Extend Life

Apples contain high levels of well-known fruit polyphenols, mainly concentrated in their skins.1 Preclinical studies have shown that apple polyphenols promote expression of genes related to cellular antioxidant enzymes and increase the lifespan of various species by 10 to 12 percent.2-5

Phloridzin Benefits

A specific apple polyphenol called phloridzin is especially active against glycation, a metabolic process that contributes to some aspects of aging. Phloridzin and phloretin (which is produced from phloridzin by intestinal bacteria) help guard against glycation by maintaining blood sugar levels already within normal range, inhibiting glycation reactions between sugars and proteins, and inhibiting glycative damage to vulnerable molecules in the body.

Phloridzin is well-known to inhibit intestinal cells’ absorption and transport of sugar into the bloodstream.6,7 One mechanism behind this effect appears to be the quelling of oxidative stress and helping support a healthy inflammatory response.8 Studies also show that phloridzin and phloretin promote normal insulin response and uptake of glucose by cells, helping to maintain normal blood glucose levels.9,10

Excess sugar molecules circulating in the bloodstream can be converted into carbonyl molecules that can then react with proteins and trigger formation of advanced glycation end-products (AGEs).11 Phloridzin and phloretin have been shown to trap existing carbonyl molecules and inhibit formation of new carbonyl compounds and AGEs.12-15

Supports Cardiovascular Health

Findings from a randomized controlled clinical trial suggest apple skin polyphenols may support heart health by encouraging healthy blood vessel function. In the study, eating apples with polyphenol-rich skins for four weeks was associated with better vascular responsiveness to blood flow than eating apples with no skins.16

Studies in animals and humans also suggest that apple polyphenols can help maintain healthy triglyceride levels already within normal range and support lipid metabolism. By blocking pancreatic lipase, an enzyme required to break down dietary triglycerides, apple polyphenols slow triglyceride absorption. By enhancing the activity of lipoprotein lipase, an enzyme that breaks down triglycerides in blood lipoproteins, they support healthy lipid metabolism.17,18  

Supports Colon Health

Polyphenols from apple skins promote colon health by scavenging oxygen free radicals, a potent means of increasing cellular mechanisms and supporting DNA function.19 They also help encourage natural antioxidant processes in intestinal cells for protection, support a healthy inflammatory response and have been shown to help protect the DNA of intestinal cells.20-23

Since health-conscious people obtain a wide range of polyphenols (such as green tea and pomegranate extracts), a daily dose of 300 mg to 600 mg of apple polyphenols may be all that is needed to obtain desired benefits.





Serving Size 1 vegetarian capsule

Amount Per Serving

Apple (Malus domestica) extract (fruit and skin) [std. to 50% polyphenols and 5% phloridzin, from organically grown apples]

600 mg

Other ingredients: vegetable cellulose (capsule), rice flour, silica, vegetable stearate.

Dosage and Use
  • Take one (1) capsule one to four times daily, or as recommended by a healthcare practitioner.
Warnings
  • KEEP OUT OF REACH OF CHILDREN
  • DO NOT EXCEED RECOMMENDED DOSE
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Shipping Overview: 

Shipping: Standard Domestic Shipping within the United States charges first item USD 6.99 and additional item USD 3.0 each. Standard International Shipping from United Kingdom, Germany, Italian and Japan to the United States charges first item USD 11.99 and additional item USD 4.0 each.

Import Duty: Everymarket collects applicable duties and taxes on goods imported into the U.S. at checkout, it's calculated based on the goods value multiply by the rate. For United Kingdom and China goods is 10%, Germany, Italian and Japan goods is 15%. We are committed to making your U.S. shopping experience simple and transparent. The method of delivery—either Delivered Duty Paid (DDP) or Delivered Duty Unpaid (DDU)—depends on whether duties and taxes are collected at the time of your purchase.

Order Processing: Please allow 1-2 business days for order processing and preparation before shipment. 

Domestic Shipping: Orders within the U.S. are shipped via USPS or FedEx, depending on the origin of the product. Average transit times to the United States is 3 - 7 Business days and average transit times to International is 7 - 14 Business days 

International Shipping: Currently, we only ship within the USA. 

Tracking Information: Every order is trackable. You will receive a tracking number once your order has been shipped. Products may be shipped from various global fulfillment centers.

Shipping Delays: 

Please note that shipping times may vary due to factors beyond our control, such as weather conditions, natural disasters, or peak holiday periods. While we strive to ensure timely delivery, the exact arrival time cannot be guaranteed and is managed by the shipping carrier.

Shipping Options:

  • Standard Delivery: Most orders are shipped within 3-7 business days. Larger items may utilize LTL shipping for safe handling.

  • Handling Time: We handle shipments on business days (Monday - Friday), with a preparation time of 1-2 days.

  • Additional Charges: Some items require additional shipping charges due to their size, weight, or special handling. These charges are specified on the product pages and are not eligible for shipping discounts.

  • Exclusions: Gift cards, packaging, taxes, and prior purchases do not count toward the minimum purchase requirement for free shipping. This offer is valid only for shipments to U.S. addresses, including Puerto Rico.

Delivery Details:

  • Estimates: Standard shipping within the US typically takes 3-7 business days. These are estimates and not guarantees.

  • Shipping Restrictions: We ship to all 50 states, Washington, DC, U.S. territories, and APO/FPO/DPO addresses. Shipping options vary based on the delivery address.

  • Remote Areas: Shipments to remote areas may incur additional charges or require pickup from a nearby shipping partner’s location.

Shipping Confirmation:

You will receive a shipping confirmation email with a tracking number as soon as your order is dispatched. If you do not receive this email immediately, please be assured that your items will arrive within the estimated delivery window provided at checkout.

Order Modifications:

If you need to cancel or modify your order, please contact our customer support immediately.

Issues with Delivery:

If your order shows as delivered but you have not received it, please contact the shipping carrier directly to resolve the issue. For persistent problems, contact our customer service at cs@everymarket.com.

Customer Support:

Our team is available 24/7 to assist you with any questions or concerns regarding your order. We are committed to ensuring a smooth shopping experience.

Return & Refund Policy Overview

Please review our return and refund policies below to ensure a smooth transaction process.

Return Policy

  • Duration: You have 30 days from receiving your item to initiate a return.

  • Condition: Items must be unworn, unwashed, with original tags and packaging intact.

  • Shipping Costs:
    - If your return is approved due to a defective, damaged, or incorrect item, we will provide a prepaid return shipping label at no cost.

    - If the item has no quality issues and matches the product listing and description, please contact our Customer Service team before returning it. Once your return is authorized, you must return the item according to the provided instructions. In this case, the return shipping cost is the customer's responsibility.

    - We are not responsible for return shipping costs for items returned without prior authorization.

  • Packaging: Ensure returned items are well-packaged to avoid damage during transit.

  • Tracking: Use a trackable and insured shipping method as we are not liable for items lost or damaged on return.

  • Initiating a Return: Contact us at cs@everymarket.com to start your return. We will provide a return shipping label and instructions upon approval. Returns without prior approval will not be accepted.

How to Return

  • Method: Returns must be sent back by mail to the address provided in the return instructions.

Return Label

  • Please contact us to get return labels.

Product Conditions for Return

  • Eligible Products: Returns are only accepted for items in new condition.

Nonreturnable Items

Certain items are not eligible for return:

  • Electronic devices after 30 days (e.g., computers, laptops, Kindles)

  • Gift cards, prepaid game cards

  • Perishable goods, live insects, some jewelry, some health and personal care items

  • Customized or personalized products

  • Items with special shipping restrictions

Refund Policy

  • Window: Eligible products may be returned within 30 days of delivery for a refund.

  • Refund Method: Refunds are processed to the original payment method or as store credit for items purchased with gift cards.

  • Processing Time: Refunds are processed within 3-5 business days after we receive the return; please allow additional time for shipping and bank processing.

Claims

Inspect your order upon arrival and report any defects, damages, or incorrect items immediately to allow us to address the issue. For claims, contact our support team with details of the issue.

Exchange Policy

For the quickest service, return your original item and place a new order for the desired product once your return is accepted.

Return Address

EveryMarket Customer Service 2101 E Terra Ln, O'Fallon, MO 63366

Customer Support

Available 24/7 for any questions or assistance needed:

  • Phone: +1 (800) 660-3783

  • Email: cs@everymarket.com

 

AppleWise

600 mg, 30 vegetarian capsules Item # 01625UPC: 737870162537




What Is AppleWise?

Like green tea and pomegranates, apples contain antioxidant-rich polyphenols. AppleWise contains an apple polyphenol called phloridzin to support healthy levels of oxidative stress and already-healthy blood sugar levels, while encouraging healthy blood vessel function. It also helps support cellular health and healthy DNA function.

Take advantage of the broad range of health benefits in this apple polyphenol-based formula for overall health.

AppleWise Benefits

  • Supports cardiovascular health
  • Supports blood sugar levels already within normal range
  • Helps inhibit oxidative stress
  • Encourages healthy cell division to support colon health



An Apple a Day for Multiple Benefits

The age-old adage about an apple a day really does hold true, as the polyphenol extracts derived from apples can help support a wide range of health benefits to maintain overall health. Primarily found in the skins of apples, the antioxidant properties of these polyphenols support heart health, colon health and healthy DNA function, promoting a comprehensive range of health benefits.




Apple polyphenols are powerful antioxidants. They help inhibit glycation and promote a healthy inflammatory response. Apple polyphenols also help support a healthy cardiovascular system, cell division, blood sugar levels already within normal range and healthy immune function.

Apple Polyphenols May Extend Life

Apples contain high levels of well-known fruit polyphenols, mainly concentrated in their skins.1 Preclinical studies have shown that apple polyphenols promote expression of genes related to cellular antioxidant enzymes and increase the lifespan of various species by 10 to 12 percent.2-5

Phloridzin Benefits

A specific apple polyphenol called phloridzin is especially active against glycation, a metabolic process that contributes to some aspects of aging. Phloridzin and phloretin (which is produced from phloridzin by intestinal bacteria) help guard against glycation by maintaining blood sugar levels already within normal range, inhibiting glycation reactions between sugars and proteins, and inhibiting glycative damage to vulnerable molecules in the body.

Phloridzin is well-known to inhibit intestinal cells’ absorption and transport of sugar into the bloodstream.6,7 One mechanism behind this effect appears to be the quelling of oxidative stress and helping support a healthy inflammatory response.8 Studies also show that phloridzin and phloretin promote normal insulin response and uptake of glucose by cells, helping to maintain normal blood glucose levels.9,10

Excess sugar molecules circulating in the bloodstream can be converted into carbonyl molecules that can then react with proteins and trigger formation of advanced glycation end-products (AGEs).11 Phloridzin and phloretin have been shown to trap existing carbonyl molecules and inhibit formation of new carbonyl compounds and AGEs.12-15

Supports Cardiovascular Health

Findings from a randomized controlled clinical trial suggest apple skin polyphenols may support heart health by encouraging healthy blood vessel function. In the study, eating apples with polyphenol-rich skins for four weeks was associated with better vascular responsiveness to blood flow than eating apples with no skins.16

Studies in animals and humans also suggest that apple polyphenols can help maintain healthy triglyceride levels already within normal range and support lipid metabolism. By blocking pancreatic lipase, an enzyme required to break down dietary triglycerides, apple polyphenols slow triglyceride absorption. By enhancing the activity of lipoprotein lipase, an enzyme that breaks down triglycerides in blood lipoproteins, they support healthy lipid metabolism.17,18  

Supports Colon Health

Polyphenols from apple skins promote colon health by scavenging oxygen free radicals, a potent means of increasing cellular mechanisms and supporting DNA function.19 They also help encourage natural antioxidant processes in intestinal cells for protection, support a healthy inflammatory response and have been shown to help protect the DNA of intestinal cells.20-23

Since health-conscious people obtain a wide range of polyphenols (such as green tea and pomegranate extracts), a daily dose of 300 mg to 600 mg of apple polyphenols may be all that is needed to obtain desired benefits.





Serving Size 1 vegetarian capsule

Amount Per Serving

Apple (Malus domestica) extract (fruit and skin) [std. to 50% polyphenols and 5% phloridzin, from organically grown apples]

600 mg

Other ingredients: vegetable cellulose (capsule), rice flour, silica, vegetable stearate.

Dosage and Use
  • Take one (1) capsule one to four times daily, or as recommended by a healthcare practitioner.
Warnings
  • KEEP OUT OF REACH OF CHILDREN
  • DO NOT EXCEED RECOMMENDED DOSE
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Shipping Overview: 

Shipping: Standard Domestic Shipping within the United States charges first item USD 6.99 and additional item USD 3.0 each. Standard International Shipping from United Kingdom, Germany, Italian and Japan to the United States charges first item USD 11.99 and additional item USD 4.0 each.

Import Duty: Everymarket collects applicable duties and taxes on goods imported into the U.S. at checkout, it's calculated based on the goods value multiply by the rate. For United Kingdom and China goods is 10%, Germany, Italian and Japan goods is 15%. We are committed to making your U.S. shopping experience simple and transparent. The method of delivery—either Delivered Duty Paid (DDP) or Delivered Duty Unpaid (DDU)—depends on whether duties and taxes are collected at the time of your purchase.

Order Processing: Please allow 1-2 business days for order processing and preparation before shipment. 

Domestic Shipping: Orders within the U.S. are shipped via USPS or FedEx, depending on the origin of the product. Average transit times to the United States is 3 - 7 Business days and average transit times to International is 7 - 14 Business days 

International Shipping: Currently, we only ship within the USA. 

Tracking Information: Every order is trackable. You will receive a tracking number once your order has been shipped. Products may be shipped from various global fulfillment centers.

Shipping Delays: 

Please note that shipping times may vary due to factors beyond our control, such as weather conditions, natural disasters, or peak holiday periods. While we strive to ensure timely delivery, the exact arrival time cannot be guaranteed and is managed by the shipping carrier.

Shipping Options:

  • Standard Delivery: Most orders are shipped within 3-7 business days. Larger items may utilize LTL shipping for safe handling.

  • Handling Time: We handle shipments on business days (Monday - Friday), with a preparation time of 1-2 days.

  • Additional Charges: Some items require additional shipping charges due to their size, weight, or special handling. These charges are specified on the product pages and are not eligible for shipping discounts.

  • Exclusions: Gift cards, packaging, taxes, and prior purchases do not count toward the minimum purchase requirement for free shipping. This offer is valid only for shipments to U.S. addresses, including Puerto Rico.

Delivery Details:

  • Estimates: Standard shipping within the US typically takes 3-7 business days. These are estimates and not guarantees.

  • Shipping Restrictions: We ship to all 50 states, Washington, DC, U.S. territories, and APO/FPO/DPO addresses. Shipping options vary based on the delivery address.

  • Remote Areas: Shipments to remote areas may incur additional charges or require pickup from a nearby shipping partner’s location.

Shipping Confirmation:

You will receive a shipping confirmation email with a tracking number as soon as your order is dispatched. If you do not receive this email immediately, please be assured that your items will arrive within the estimated delivery window provided at checkout.

Order Modifications:

If you need to cancel or modify your order, please contact our customer support immediately.

Issues with Delivery:

If your order shows as delivered but you have not received it, please contact the shipping carrier directly to resolve the issue. For persistent problems, contact our customer service at cs@everymarket.com.

Customer Support:

Our team is available 24/7 to assist you with any questions or concerns regarding your order. We are committed to ensuring a smooth shopping experience.

Return & Refund Policy Overview

Please review our return and refund policies below to ensure a smooth transaction process.

Return Policy

  • Duration: You have 30 days from receiving your item to initiate a return.

  • Condition: Items must be unworn, unwashed, with original tags and packaging intact.

  • Shipping Costs:
    - If your return is approved due to a defective, damaged, or incorrect item, we will provide a prepaid return shipping label at no cost.

    - If the item has no quality issues and matches the product listing and description, please contact our Customer Service team before returning it. Once your return is authorized, you must return the item according to the provided instructions. In this case, the return shipping cost is the customer's responsibility.

    - We are not responsible for return shipping costs for items returned without prior authorization.

  • Packaging: Ensure returned items are well-packaged to avoid damage during transit.

  • Tracking: Use a trackable and insured shipping method as we are not liable for items lost or damaged on return.

  • Initiating a Return: Contact us at cs@everymarket.com to start your return. We will provide a return shipping label and instructions upon approval. Returns without prior approval will not be accepted.

How to Return

  • Method: Returns must be sent back by mail to the address provided in the return instructions.

Return Label

  • Please contact us to get return labels.

Product Conditions for Return

  • Eligible Products: Returns are only accepted for items in new condition.

Nonreturnable Items

Certain items are not eligible for return:

  • Electronic devices after 30 days (e.g., computers, laptops, Kindles)

  • Gift cards, prepaid game cards

  • Perishable goods, live insects, some jewelry, some health and personal care items

  • Customized or personalized products

  • Items with special shipping restrictions

Refund Policy

  • Window: Eligible products may be returned within 30 days of delivery for a refund.

  • Refund Method: Refunds are processed to the original payment method or as store credit for items purchased with gift cards.

  • Processing Time: Refunds are processed within 3-5 business days after we receive the return; please allow additional time for shipping and bank processing.

Claims

Inspect your order upon arrival and report any defects, damages, or incorrect items immediately to allow us to address the issue. For claims, contact our support team with details of the issue.

Exchange Policy

For the quickest service, return your original item and place a new order for the desired product once your return is accepted.

Return Address

EveryMarket Customer Service 2101 E Terra Ln, O'Fallon, MO 63366

Customer Support

Available 24/7 for any questions or assistance needed:

  • Phone: +1 (800) 660-3783

  • Email: cs@everymarket.com

 

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