果蝇已被研究生物学家研究了100多年,本书围绕果蝇研究的讲述了20多个故事,有关果蝇的学习、记忆、癌症、衰老、生物节律、睡眠、性、干细胞、成瘾、肥胖、运动、感染、再生等都有故事,形象生动的语言和精彩的图片阐述不但使人了解果蝇本身,更让读者体会到科学发展的艰辛历程。
果蝇作为模式生物,已被研究了100多年,很多生物学新知识是从研究果蝇得到的。本书围绕果蝇的方方面面讲述了20多个故事,学科多,视野开阔。涉及的学科有发育生物学、遗传学、生物化学、细胞生物学、神经科学、动物行为学、进化学、免疫学等,相关的话题有学习、记忆、癌症、衰老、生物节律、睡眠、性、干细胞、成瘾、肥胖、运动、感染、再生等。并在保证科学性和准确性的前提下,用形象生动的语言和精彩的图片阐述果蝇研究的各个方面。相关的科学史内容使读者在接受科学知识的同时,体会到科学发展的艰辛历程,从而起到宣扬科学精神的教育效果。
刘冀珑:上海科技大学生命科学与技术学院教授,副院长。实验室以果蝇、酵母菌以及人培养细胞为主要研究材料探索代谢酶(如CTP合成酶和IMP脱氢酶等)在细胞里如何被区域化。 CTP合成酶和IMP脱氢酶是研究抗癌,抗寄生虫和抗病毒药物的极具前景的标靶。将致力于研究不同代谢酶如何组装成细胞蛇,以及细胞蛇和类似细胞器如何在代谢调控和肿瘤生物学发挥作用。
|第 1 章| 果蝇与性 / 001
|第 2 章| 果蝇与诞生 / 009
|第 3 章| 果蝇与成长 / 017
|第 4 章| 果蝇与衰老长寿 / 023
|第 5 章| 果蝇与疾病 / 033
|第 6 章| 果蝇与愈合再生 / 043
|第 7 章| 果蝇与免疫 / 049
|第 8 章| 果蝇与死亡 / 055
|第 9 章| 果蝇与癌症 / 061
|第10章| 果蝇与干细胞 / 069
|第11章| 果蝇与肥胖代谢 / 077
|第12章| 果蝇与学习记忆 / 085
|第13章| 果蝇与生物钟 / 095
和冀珑相识于美国遗传学会举办的果蝇年会。当时我刚在佛罗里达州立大学建立起自己的果蝇实验室不久,冀珑还在卡内基研究所做博士后,其后去牛津成立了自己的实验室。2011年在克里特岛上的一个果蝇研讨会上,我们同住一室,当时就有了在国内举办同样的果蝇研究PI会议的想法。冀珑后来去了上海科技大学,几经周折,在其老家同学帮助下,终于有了届(2016年)和第二届(2018年)的九江国际果蝇会议。该书大多数作者也是九江果蝇会议的参与者。
关于果蝇,很多人看到都会觉得恶心、讨厌,会不自觉地将其与苍蝇联系起来。中文里形容“蝇”的多是贬义词,比如“蝇头小利”“如蝇逐臭”“蝇营狗苟”之类。虽然说的是苍蝇,但果蝇也连带受累,似乎蝇皆一无是处。然而,果蝇确实与众不同,在被生物学家选作实验材料以后,对于生物学之贡献无出其右者。以果蝇为实验主要对象而获得诺贝尔奖的就有5次;以果蝇为材料的工作,真真实实地给生物学的各个分支都带来了开创性的突破。
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